P028 Inflammatory cytokines specifically regulate endoplasmic reticulum stress in colitis

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases

As an adaptive response to the overloading with misfolded proteins in the endoplasmic reticulum (ER), ER stress plays critical roles in maintaining protein homeostasis in the secretory pathway to avoid damage to the host. Such a conserved mechanism is accomplished through three well-orchestrated pathways known collectively as unfolded protein response (UPR). Persistent and pathological ER stres...

Involvement of Endoplasmic Reticulum Stress Response in Orofacial Inflammatory Pain

Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little data on the role of the ER stress response in pain mechanisms. In this study, we explored whether the ER stress response is involved in orofacial inflammatory pain by using...

Inflammatory Cytokines Regulate Function

Inflammatory bowel disease, stress, and the endoplasmic reticulum.

The causes of Crohn’s disease and ulcerative colitis are poorly understood, despite having been defined many decades ago on the basis of their clinical manifestations. Experiments involving transgenic mice and genomewide association studies involving patients have independently provided glimpses into the complexity of the genetic causes of these disorders. A recent study described by Kaser and ...

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's adaptive capacity results in activation of the unfolded protein response (UPR), which intersects with many different inflammatory and stress signaling pathways. These pathways are also critical in chronic metabolic diseases such as obesi...